Issue 13, 2019

Mitochondrial directed ratiometric fluorescent probe for quantitive detection of sulfur dioxide derivatives

Abstract

We herein report a ratiometric fluorescent probe, MN, capable of determining SO32−/HSO3 in mitochondria. The probe specifically responds to SO32−/HSO3 and is not interfered with by other biological mercaptans or anions. The LOD of the probe is 85 nM, making it a feasible sensor to image SO32−/HSO3. With good membrane permeability and low cytotoxicity, MN was successfully used in the ratiometric detection of SO32−/HSO3 in mitochondria.

Graphical abstract: Mitochondrial directed ratiometric fluorescent probe for quantitive detection of sulfur dioxide derivatives

Supplementary files

Article information

Article type
Paper
Submitted
23 Nov 2018
Accepted
22 Jan 2019
First published
25 Jan 2019

New J. Chem., 2019,43, 5255-5259

Mitochondrial directed ratiometric fluorescent probe for quantitive detection of sulfur dioxide derivatives

C. Gao, Y. Tian, R. Zhang, J. Jing and X. Zhang, New J. Chem., 2019, 43, 5255 DOI: 10.1039/C8NJ05951A

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