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Issue 10, 2019
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Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

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Abstract

Herein we describe the synthesis of artemisinin based glycoconjugates (9a–i) through employing a Cu(I)-catalysed reaction between β-propargylated dihydroartemisinin (7a) and azido sugars (8a–i), with moderate to excellent yields. Our synthesized artemisinin based glycoconjugates (9a–i) could prove to be an interesting class of bioactive molecules, suitable for the study of their various biological activities.

Graphical abstract: Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

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Publication details

The article was received on 12 Nov 2018, accepted on 11 Feb 2019 and first published on 11 Feb 2019


Article type: Letter
DOI: 10.1039/C8NJ05737K
New J. Chem., 2019,43, 4017-4021

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    Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

    L. Goswami, S. Paul, T. K. Kotammagari and A. K. Bhattacharya, New J. Chem., 2019, 43, 4017
    DOI: 10.1039/C8NJ05737K

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