Issue 11, 2019
From the journal:

Nanoscale Advances

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations†

James J. Hobson,a   Paul Curley,b   Alison C. Savage,a   Amer Al-khouja,c   Marco Siccardi,b   Charles Flexner,cd   Caren Freel Meyers,c   Andrew Owenb  and  Steve P. Rannard ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK
E-mail: srannard@liv.ac.uk

b Department of Molecular and Clinical Pharmacology, University of Liverpool, Block H, 70 Pembroke Place, Liverpool L69 3GF, UK

c Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA

d Department of Medicine, The Johns Hopkins University School of Medicine, 575 Osler Building, 600 N. Wolfe St., Baltimore, MD 21287, USA

Abstract

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

Graphical abstract: Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

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Article information

DOI
https://doi.org/10.1039/C9NA00529C
Article type
Communication
Submitted
23 Aug 2019
Accepted
07 Oct 2019
First published
12 Oct 2019
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2019,1, 4301-4307

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Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

J. J. Hobson, P. Curley, A. C. Savage, A. Al-khouja, M. Siccardi, C. Flexner, C. F. Meyers, A. Owen and S. P. Rannard, Nanoscale Adv., 2019, 1, 4301 DOI: 10.1039/C9NA00529C

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