SCHEDULED MAINTENANCE
Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study†
Pasquale
Linciano, 
‡a
Barbara
De Filippis,
‡b
Alessandra
Ammazzalorso,
b
Pasquale
Amoia,
b
Felisa
Cilurzo,
b
Marialuigia
Fantacuzzi,
b
Letizia
Giampietro,
b
Cristina
Maccallini,
b
Charlotte
Petit
c
and
Rosa
Amoroso
*b
‡a
Barbara
De Filippis,
‡b
Alessandra
Ammazzalorso,
b
Pasquale
Amoia,
b
Felisa
Cilurzo,
b
Marialuigia
Fantacuzzi,
b
Letizia
Giampietro,
b
Cristina
Maccallini,
b
Charlotte
Petit
c
and
Rosa
Amoroso
*b
Abstract
PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In this study, we assayed some PPAR agonists previously synthesized by us for their physicochemical properties, with particular references to lipophilicity, solubility and permeability profiles, using the PAMPA. Although tested compounds showed high lipophilicity and low aqueous solubility, the results revealed a good overall druggability profile, encouraging further studies in the field of neurodegenerative diseases.
Please wait while we load your content...
