Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

Anna A. Nazarova; Kseniya N. Sedenkova; Dmitry S. Karlov; Mstislav I. Lavrov; Yuri K. Grishin; Tamara S. Kuznetsova; Vladimir L. Zamoyski; Vladimir V. Grigoriev; Elena B. Averina; Vladimir A. Palyulin

doi:10.1039/C9MD00262F

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series†

Anna A. Nazarova,^a Kseniya N. Sedenkova,

^ab Dmitry S. Karlov,

^ac Mstislav I. Lavrov,^ab Yuri K. Grishin,^a Tamara S. Kuznetsova,^a Vladimir L. Zamoyski,^b Vladimir V. Grigoriev,^ab Elena B. Averina

*^ab and Vladimir A. Palyulin

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russian Federation
E-mail: elaver@med.chem.msu.ru, vap@qsar.chem.msu.ru
Fax: +7 (495) 939 0290

^b Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation

^c Center for Computational and Data-intensive Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, Russian Federation

Abstract

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.

MedChemComm

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

Search articles by author

Spotlight

Advertisements