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Issue 7, 2019
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Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

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Abstract

The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2–50 μM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.

Graphical abstract: Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

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Supplementary files

Article information


Submitted
28 Feb 2019
Accepted
29 Apr 2019
First published
08 May 2019

Med. Chem. Commun., 2019,10, 1205-1211
Article type
Research Article
Author version available

Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues

A. Z. Aljahdali, S. A. Freedman, J. Scott, M. Li and G. A. O'Doherty, Med. Chem. Commun., 2019, 10, 1205
DOI: 10.1039/C9MD00121B

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