Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

T. Vu Nguyen; Matthew T. Peszko; Roberta J. Melander; Christian Melander

doi:10.1039/C9MD00025A

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Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation†

T. Vu Nguyen,^a Matthew T. Peszko,^a Roberta J. Melander

^b and Christian Melander

*^b

Author affiliations

* Corresponding authors

^a Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA

^b Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
E-mail: cmelande@nd.edu

Abstract

Biofilm formation by mycobacteria can lead to enhanced antibiotic tolerance. Herein, we report on the identification of a series of 2-aminobenzimidazole (2-ABI) derivatives that potently inhibit biofilm formation by Mycobacterium smegmatis.

This article is part of the themed collection: Antimicrobial Resistance

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Article information

DOI: https://doi.org/10.1039/C9MD00025A
Article type: Research Article
Submitted: 14 Jan 2019
Accepted: 07 Feb 2019
First published: 12 Feb 2019

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Med. Chem. Commun., 2019,10, 456-459

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Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

T. V. Nguyen, M. T. Peszko, R. J. Melander and C. Melander, Med. Chem. Commun., 2019, 10, 456 DOI: 10.1039/C9MD00025A

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Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation†

Abstract

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Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

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