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Issue 17, 2019
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Integrated microfluidic systems with sample preparation and nucleic acid amplification

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Abstract

Rapid, efficient and accurate nucleic acid molecule detection is important in the screening of diseases and pathogens, yet remains a limiting factor at point of care (POC) treatment. Microfluidic systems are characterized by fast, integrated, miniaturized features which provide an effective platform for qualitative and quantitative detection of nucleic acid molecules. The nucleic acid detection process mainly includes sample preparation and target molecule amplification. Given the advancements in theoretical research and technological innovations to date, nucleic acid extraction and amplification integrated with microfluidic systems has advanced rapidly. The primary goal of this review is to outline current approaches used for nucleic acid detection in the context of microfluidic systems. The secondary goal is to identify new approaches that will help shape future trends at the intersection of nucleic acid detection and microfluidics, particularly with regard to increasing disease and pathogen detection for improved diagnosis and treatment.

Graphical abstract: Integrated microfluidic systems with sample preparation and nucleic acid amplification

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Article information


Submitted
23 Apr 2019
Accepted
18 Jul 2019
First published
31 Jul 2019

Lab Chip, 2019,19, 2769-2785
Article type
Critical Review

Integrated microfluidic systems with sample preparation and nucleic acid amplification

J. Yin, Y. Suo, Z. Zou, J. Sun, S. Zhang, B. Wang, Y. Xu, D. Darland, J. X. Zhao and Y. Mu, Lab Chip, 2019, 19, 2769
DOI: 10.1039/C9LC00389D

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