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Issue 16, 2019
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High-speed microparticle isolation unlimited by Poisson statistics

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High-speed isolation of microparticles (e.g., microplastics, heavy metal particles, microbes, cells) from heterogeneous populations is the key element of high-throughput sorting instruments for chemical, biological, industrial and medical applications. Unfortunately, the performance of continuous microparticle isolation or so-called sorting is fundamentally limited by the trade-off between throughput, purity, and yield. For example, at a given throughput, high-purity sorting needs to sacrifice yield, or vice versa. This is due to Poisson statistics of events (i.e., microparticles, microparticle clusters, microparticle debris) in which the interval between successive events is stochastic and can be very short. Here we demonstrate an on-chip microparticle sorter with an ultrashort switching window in both time (10 μs) and space (10 μm) at a high flow speed of 1 m s−1, thereby overcoming the Poisson trade-off. This is made possible by using femtosecond laser pulses that can produce highly localized transient cavitation bubbles in a microchannel to kick target microparticles from an acoustically focused, densely aligned, bumper-to-bumper stream of microparticles. Our method is important for rare-microparticle sorting applications where both high purity and high yield are required to avoid missing rare microparticles.

Graphical abstract: High-speed microparticle isolation unlimited by Poisson statistics

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Publication details

The article was received on 08 Apr 2019, accepted on 25 Jun 2019 and first published on 23 Jul 2019

Article type: Paper
DOI: 10.1039/C9LC00324J
Lab Chip, 2019,19, 2669-2677

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    High-speed microparticle isolation unlimited by Poisson statistics

    T. Iino, K. Okano, S. W. Lee, T. Yamakawa, H. Hagihara, Z. Hong, T. Maeno, Y. Kasai, S. Sakuma, T. Hayakawa, F. Arai, Y. Ozeki, K. Goda and Y. Hosokawa, Lab Chip, 2019, 19, 2669
    DOI: 10.1039/C9LC00324J

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