Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2019
Previous Article Next Article

Generating digital drug cocktails via optical manipulation of drug-containing particles and photo-patterning of hydrogels

Author affiliations

Abstract

An integrated microfluidic system combining 1) an optically-induced-dielectrophoresis (ODEP) module for manipulation of drug-containing particles and 2) an ultraviolet (UV) “direct writing” module capable of patterning hydrogels was established herein for automatic formulation of customized digital drug cocktails. Using the ODEP module, the drug-containing particles were assembled by using moving light patterns generated from a digital projector. The hydrogel, poly(ethylene glycol) diacrylate (PEGDA), was used as the medium in the ODEP module such that the assembled drug-containing particles could be UV-cured and consequently encapsulated in “pills” of specific sizes and shapes by using the UV direct writing module. At an optimal ODEP force of 335 pN, which was achieved in a solution of 15% PEGDA in 0.2 M sucrose, it was possible to manipulate and UV-cure the drug-containing particles. Furthermore, with a digital micromirror device inside the UV direct writing module, different UV patterns could be designed and projected, allowing for the digital drug cocktails to be packaged into different shapes in <60 s. As a demonstration, emulsion droplets containing two different anti-cancer drugs were further tested to show the capability of the developed device. This represents an automatic digital drug cocktail formulating device which stands to revolutionize personalized medicine.

Graphical abstract: Generating digital drug cocktails via optical manipulation of drug-containing particles and photo-patterning of hydrogels

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Feb 2019, accepted on 22 Mar 2019 and first published on 26 Mar 2019


Article type: Paper
DOI: 10.1039/C9LC00189A
Lab Chip, 2019,19, 1764-1771

  •   Request permissions

    Generating digital drug cocktails via optical manipulation of drug-containing particles and photo-patterning of hydrogels

    Y. Chen, K. Chung, W. Huang, W. Lee, C. Fu, C. Wang and G. Lee, Lab Chip, 2019, 19, 1764
    DOI: 10.1039/C9LC00189A

Search articles by author

Spotlight

Advertisements