Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2019
Previous Article Next Article

Semi-automated on-demand control of individual droplets with a sample application to a drug screening assay

Author affiliations

Abstract

Automated control of individual droplets in microfluidic channels offers tremendous potential for applications requiring high accuracy and minimal user involvement. The feasibility of active droplet control has been previously demonstrated with pressure-driven flow control and visual feedback, but the manual operation required to perform droplet manipulations limited the accuracy, repeatability, and throughput. The present study improves upon the aforementioned challenges with a higher-level algorithm capturing the dynamics of droplet motion for a semi-automated control system. With a simple T junction geometry, droplets can now be automatically and precisely controlled on-demand. Specifically, there is ±10% accuracy for droplet generation, ±1.3% monodispersity for 500 μm long droplets and ±4% accuracy for splitting ratios. On-demand merging, mixing, and sorting are also demonstrated as well as the application of a drug screening assay related to neurodegenerative disorders. Overall, this system serves as a foundation for a fully automated system that does not require valves, embedded electrodes, or complex multi-layer fabrication.

Graphical abstract: Semi-automated on-demand control of individual droplets with a sample application to a drug screening assay

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Feb 2019, accepted on 18 Mar 2019 and first published on 19 Mar 2019


Article type: Paper
DOI: 10.1039/C9LC00128J
Lab Chip, 2019,19, 1490-1501

  •   Request permissions

    Semi-automated on-demand control of individual droplets with a sample application to a drug screening assay

    M. Hébert, M. Courtney and C. L. Ren, Lab Chip, 2019, 19, 1490
    DOI: 10.1039/C9LC00128J

Search articles by author

Spotlight

Advertisements