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Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system

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Abstract

We have developed a highly integrated lab-on-a-chip containing embedded electrical microsensors, μdegassers and pneumatically-actuated micropumps to monitor allergic hypersensitivity. Rapid antigen-mediated histamine release (e.g. s to min) and resulting muscle contraction (<30 min) is detected by connecting an immune compartment containing sensitized basophile cells to a vascular co-culture model.

Graphical abstract: Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system

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Publication details

The article was received on 31 Jan 2019, accepted on 23 Apr 2019 and first published on 23 Apr 2019


Article type: Communication
DOI: 10.1039/C9LC00108E
Lab Chip, 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system

    M. Rothbauer, V. Charwat, B. Bachmann, D. Sticker, R. Novak, H. Wanzenböck, R. A. Mathies and P. Ertl, Lab Chip, 2019, Advance Article , DOI: 10.1039/C9LC00108E

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