Storing and releasing rhodamine as a model hydrophobic compound in polydimethylsiloxane microfluidic devices

Abstract

Polydimethylsiloxane (PDMS) is a ubiquitous material used in soft lithography and microfluidics. Due to its hydrophobic nature, PDMS tends to absorb small hydrophobic molecules, and is seen as a major disadvantage of the material in pharmaceutical and cell culture studies. While there have been extensive reports of attempts to treat PDMS to limit or block this absorption, little attention has been given to using this property as a feature in microfluidic devices. In this work, we leverage the ability of PDMS to store hydrophobic molecules inside the PDMS matrix and release them over time in a sustained manner.