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Issue 7, 2019
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Separating extracellular vesicles and lipoproteins via acoustofluidics

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Abstract

Extracellular vesicles (EVs) and lipoproteins are abundant and co-exist in blood. Both have been proven to be valuable as diagnostic biomarkers and for therapeutics. However, EVs and lipoproteins are both on the submicron scale and overlap in size distributions. Conventional methods to separate EVs and lipoproteins are inefficient and time-consuming. Here we present an acoustofluidic-based separation technique that is based on the acoustic property differences of EVs and lipoproteins. By using the acoustofluidic technology, EVs and subgroups of lipoproteins are separated in a label-free, contact-free, and continuous manner. With its ability for simple, rapid, efficient, continuous-flow isolation, our acoustofluidic technology could be a valuable tool for health monitoring, disease diagnosis, and personalized medicine.

Graphical abstract: Separating extracellular vesicles and lipoproteins via acoustofluidics

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Publication details

The article was received on 22 Oct 2018, accepted on 15 Feb 2019 and first published on 18 Feb 2019


Article type: Paper
DOI: 10.1039/C8LC01134F
Lab Chip, 2019,19, 1174-1182

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    Separating extracellular vesicles and lipoproteins via acoustofluidics

    M. Wu, C. Chen, Z. Wang, H. Bachman, Y. Ouyang, P. Huang, Y. Sadovsky and T. J. Huang, Lab Chip, 2019, 19, 1174
    DOI: 10.1039/C8LC01134F

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