Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2019
Previous Article Next Article

Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application

Author affiliations

Abstract

Substantial research has been devoted to elucidate the roles that extracellular vesicles (EVs) play in the regulation of both normal and pathological processes, and multiple studies have demonstrated their potential as a source of cancer biomarkers. However, several factors have slowed the development of liquid biopsy EV biomarkers for cancer diagnosis, including logistical and technical difficulties associated with reproducibly obtaining highly purified EVs suitable for diagnostic analysis. Significant effort has focused on addressing these problems, and multiple groups have now reported EV analysis methods using liquid biopsies that have the potential for clinical translation. However, there are still important issues that must be addressed if these discoveries and technical advances are to be used for clinical translation of EV cancer biomarkers from liquid biopsies. To address these issues, this review focuses on the potential application of EV biomarkers for diagnosis of major cancer types, discussing approaches for EV biomarker discovery and verification, EV clinical assay development, analytical and clinical validation, clinical trials, regulatory submission, and end user utilization for the intended clinical application. This review also discusses key difficulties related to these steps, and recommendations for how to best accomplish steps in order to translate EV-based biomarkers into clinical settings.

Graphical abstract: Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application

Back to tab navigation

Publication details

The article was received on 20 Oct 2018, accepted on 04 Mar 2019 and first published on 05 Mar 2019


Article type: Tutorial Review
DOI: 10.1039/C8LC01123K
Lab Chip, 2019,19, 1114-1140

  •   Request permissions

    Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application

    Z. Zhao, J. Fan, Y. S. Hsu, C. J. Lyon, B. Ning and T. Y. Hu, Lab Chip, 2019, 19, 1114
    DOI: 10.1039/C8LC01123K

Search articles by author

Spotlight

Advertisements