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Issue 3, 2019
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Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

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Abstract

Platelet separation is a crucial step for both blood donation and treatment of essential thrombocytosis. Here we present an acoustofluidic device that is capable of performing high-throughput, biocompatible platelet separation using sound waves. The device is entirely made of plastic material, which renders the device disposable and more suitable for clinical use. We used this device to process undiluted human whole blood, and we demonstrate a sample throughput of 20 mL min−1, a platelet recovery rate of 87.3%, and a red/white blood cell removal rate of 88.9%. We preserved better platelet function and integrity for isolated platelets than those which are isolated using established methods. Our device features advantages such as rapid fabrication, high throughput, and biocompatibility, so it is a promising alternative to existing platelet separation approaches.

Graphical abstract: Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

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Publication details

The article was received on 24 May 2018, accepted on 19 Dec 2018 and first published on 11 Jan 2019


Article type: Paper
DOI: 10.1039/C8LC00527C
Citation: Lab Chip, 2019,19, 394-402

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    Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation

    Y. Gu, C. Chen, Z. Wang, P. Huang, H. Fu, L. Wang, M. Wu, Y. Chen, T. Gao, J. Gong, J. Kwun, G. M. Arepally and T. J. Huang, Lab Chip, 2019, 19, 394
    DOI: 10.1039/C8LC00527C

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