Issue 23, 2019

Use of a switchable-hydrophilicity solvent as both a solvent and a catalyst in aldol condensation

Abstract

A switchable-hydrophilicity solvent, N,N-dimethylcyclohexylamine, was used as a recyclable catalyst and solvent for aldol condensation, giving >97% pure product in 94% isolated yield without the need for purification or additional solvents. CO2-triggered separation produced yields greater than conventional workup and allowed facile recycling of the amine.

Graphical abstract: Use of a switchable-hydrophilicity solvent as both a solvent and a catalyst in aldol condensation

Supplementary files

Article information

Article type
Communication
Submitted
25 Jul 2019
Accepted
06 Nov 2019
First published
06 Nov 2019

Green Chem., 2019,21, 6263-6267

Use of a switchable-hydrophilicity solvent as both a solvent and a catalyst in aldol condensation

H. Poole, J. Gauthier, J. R. Vanderveen, P. G. Jessop and R. Lee, Green Chem., 2019, 21, 6263 DOI: 10.1039/C9GC02593F

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