Issue 15, 2019

A visible-light-induced intermolecular [3 + 2] alkenylation–cyclization strategy: metal-free construction of pyrrolo[2,1,5-cd]indolizine rings

Abstract

A simple and efficient visible-light-induced intermolecular [3 + 2] alkenylation–cyclization process has been developed. This reaction provided an unprecedented metal-free double C(sp2)–H bond oxidation coupling of indolizines with electron-deficient alkenes. Through this cascade reaction, a series of pyrrolo[2,1,5-cd]indolizine derivatives with a large π-system were synthesized. Furthermore, this approach features easily available starting materials, good functional group tolerance, step-economy, high efficiency and mild conditions.

Graphical abstract: A visible-light-induced intermolecular [3 + 2] alkenylation–cyclization strategy: metal-free construction of pyrrolo[2,1,5-cd]indolizine rings

Supplementary files

Article information

Article type
Communication
Submitted
28 May 2019
Accepted
01 Jul 2019
First published
02 Jul 2019

Green Chem., 2019,21, 4025-4029

A visible-light-induced intermolecular [3 + 2] alkenylation–cyclization strategy: metal-free construction of pyrrolo[2,1,5-cd]indolizine rings

Y. Liang, L. Teng, Y. Wang, Q. He and H. Cao, Green Chem., 2019, 21, 4025 DOI: 10.1039/C9GC01766F

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