Issue 14, 2019

Visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with sulfinic acids

Abstract

The first example of visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with sulfinic acids in the presence of an organic dye as the catalyst was developed. The reaction conditions are eco-friendly and mild, employing ambient air as the sole oxidant and aqueous acetone solution as the solvent. This approach requires only a very low catalyst loading, allowing gram-scale preparation as well as late-stage modification of biologically active compounds bearing quinoline groups.

Graphical abstract: Visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with sulfinic acids

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2019
Accepted
18 Jun 2019
First published
26 Jun 2019

Green Chem., 2019,21, 3858-3863

Visible-light-induced deoxygenative C2-sulfonylation of quinoline N-oxides with sulfinic acids

L. Xie, T. Fang, J. Tan, B. Zhang, Z. Cao, L. Yang and W. He, Green Chem., 2019, 21, 3858 DOI: 10.1039/C9GC01175G

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