Issue 11, 2019
From the journal:

Green Chemistry

A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO†

Wei-Guo Shen,‡a   Qing-Yan Wu,‡a   Xing-Yu Gong,a   Gui-Zhen Aoa  and  Feng Liu ORCID logo *ab  

* Corresponding authors

a Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's Republic of China
E-mail: fliu2@suda.edu.cn

b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China

Abstract

A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.

Graphical abstract: A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9GC00886A
Article type
Paper
Submitted
14 Mar 2019
Accepted
22 Apr 2019
First published
24 Apr 2019

Green Chem., 2019,21, 2983-2987

Permissions

Request permissions

A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

W. Shen, Q. Wu, X. Gong, G. Ao and F. Liu, Green Chem., 2019, 21, 2983 DOI: 10.1039/C9GC00886A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements