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Issue 1, 2019
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A solvent-free catalytic protocol for the Achmatowicz rearrangement

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Abstract

Reported here is the development of an environmentally friendly catalytic (KBr/oxone) and solvent-free protocol for the Achmatowicz rearrangement (AchR). Different from all previous methods is that the use of chromatographic alumina (Al2O3) allows AchR to proceed smoothly in the absence of any organic solvent and therefore considerably facilitates the subsequent workup and purification with minimal environmental impacts. Importantly, this protocol allows for scaling up (from milligram to gram), recycling of the Al2O3, and integrating with other reactions in a one-pot sequential manner.

Graphical abstract: A solvent-free catalytic protocol for the Achmatowicz rearrangement

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Publication details

The article was received on 26 Sep 2018, accepted on 17 Nov 2018 and first published on 19 Nov 2018


Article type: Communication
DOI: 10.1039/C8GC03030H
Green Chem., 2019,21, 64-68

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    A solvent-free catalytic protocol for the Achmatowicz rearrangement

    G. Zhao and R. Tong, Green Chem., 2019, 21, 64
    DOI: 10.1039/C8GC03030H

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