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GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABAAR signaling and AMPK-autophagy pathway

Abstract

Enterotoxigenic Escherichia coli (ETEC) triggers diarrhea in humans and livestock. We have previously showed that ETEC promotes intestinal epithelial cell apoptosis and increases gamma-aminobutyric acid (GABA) concentration in the jejunum, suggesting that GABA might mediate ETEC-induced apoptosis. Here, we found that GABA alleviates ETEC-induced intestinal barrier dysfunctions, including ETEC-induced apoptosis both in vivo and in vitro. Interestingly, the alleviation of GABA on ETEC-induced apoptosis largely depends on autophagy. Mechanistically, GABA attenuates ETEC-induced apoptosis via activating GABAAR signaling and AMPK-autophagy pathway. These findings highlight that maintaining intestinal GABA concentration could alleviate intestinal ETEC infection.

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Publication details

The article was received on 16 Aug 2019, accepted on 05 Oct 2019 and first published on 09 Oct 2019


Article type: Paper
DOI: 10.1039/C9FO01863H
Food Funct., 2019, Accepted Manuscript

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    GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABAAR signaling and AMPK-autophagy pathway

    Y. xia, S. Chen, Y. zhao, S. Chen, R. Huang, G. Zhu, Y. Yin, W. Ren and J. Deng, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO01863H

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