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Banana flour phenolics inhibit trans-epithelial glucose transport from wheat cakes in a coupled in vitro digestion/Caco-2 cell intestinal model

Abstract

Some fruit phenolics are reported to attenuate intestinal glucose transport through inhibitory action at the luminal brush border membrane. This effect may contribute, in part, to the ability of flavonoid-rich foods to regulate glucose homeostasis of meals rich in available carbohydrates. For the first time, the potential of green banana flours to inhibit transepithelial glucose transport was investigated in the context of a model starchy meal (wheat cake) using a simulated digestion/Caco-2 human intestinal cell model. A 10 % replacement of wheat flour by any of the four banana flours (native and extruded oven-dried and freeze-dried) resulted in cakes with significantly higher total phenolics (68-198 μg/100g, p < 0.05), especially using extruded banana flours (197-198 μg/100g), as measured by LC/MS. Banana cakes, especially those containing oven-dried and/or extruded banana flours, exhibited from 45.0 to 54.5 % higher glucose transport inhibitions than the control cake. Interestingly, the digesta of cakes made with freeze-dried-extruded banana flour presented a significantly higher phenolic content (1116 μM, p < 0.05) than the other digestas (745-791 μM), while control digesta was only 548 μM. These results suggested that the amounts of quercetin and myricetin, even in traces, were critical determinants on glucose transport inhibition.

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Publication details

The article was received on 26 Jul 2019, accepted on 09 Sep 2019 and first published on 10 Sep 2019


Article type: Paper
DOI: 10.1039/C9FO01679A
Food Funct., 2019, Accepted Manuscript

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    Banana flour phenolics inhibit trans-epithelial glucose transport from wheat cakes in a coupled in vitro digestion/Caco-2 cell intestinal model

    J. Pico, S. Corbin, M. G. Ferruzzi and M. M. Martinez, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C9FO01679A

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