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Issue 12, 2019
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Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways

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Abstract

Metastasis is the most prevalent cause of treatment failure in patients with colon cancer. Gossypol is reported to exhibit antioxidant, anticancer, antivirus and antimicrobial properties. However, the effects of gossypol on cancer invasion and tumour growth of human colon cancer remain unclear. This study aimed to provide molecular evidence associated with the antimetastatic and anti-tumour effects of gossypol on human colorectal carcinoma (CRC) cells. Gossypol inhibited the viability of human colon cancer cells in a dose-dependent manner. Gossypol was sufficient to reduce the invasion, migration and adhesion in DLD-1 and COLO 205 cells. Zymography and western blot assay showed that gossypol reduced the activities and protein expression of urokinase-type plasminogen activator (u-PA), respectively. Gossypol suppressed the level of p-focal adhesion kinase (FAK) and epithelial-to-mesenchymal transition markers, including N-cadherin, fibronectin and vimentin. Gossypol also inhibited the lung metastasis of DLD-1 cells, as indicated by the nude mouse model. These results suggested that gossypol inhibited the metastatic properties of human colon cancer cells by targeting u-PA through the FAK pathway, suggesting that gossypol could be used as an adjuvant therapeutic agent for the treatment of human colon cancer cells.

Graphical abstract: Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways

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Article information


Submitted
19 Jun 2019
Accepted
19 Oct 2019
First published
21 Oct 2019

Food Funct., 2019,10, 8172-8181
Article type
Paper

Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways

S. Huang, S. Chu, L. Hsu, Y. Tu, P. Chen and Y. Hsieh, Food Funct., 2019, 10, 8172
DOI: 10.1039/C9FO01306G

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