Issue 7, 2019

Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo

Abstract

Colorectal carcinoma (CRC) is an aggressive malignancy with very limited therapeutic options. As a result, both morbidity and mortality of this malignancy are very high. It is well-established that Nostoc commune Vaucher is a type of healthy food and has been used as a traditional medicine against human cancers. However, the underlying mechanism(s) by which Nostoc commune Vaucher inhibits CRC was never described. Here we reported that polysaccharides from Nostoc commune Vaucher are a potent inhibitor of CRC growth by activating macrophages. Specifically, we purified polysaccharides from Nostoc commune and two fractions of these polysaccharides are able to inhibit the proliferation and growth of five human CRC cell lines with divergent genetic backgrounds. Through activating NF-κB and AKT/JNK1/2 signaling pathways, one fraction of polysaccharides significantly activated macrophages, which was reflected by the enlarged size of macrophages, enhanced phagocytosis and expression of TNF-α and IL-1β. In summary, this study demonstrated that the polysaccharides from Nostoc commune Vaucher are a potent activator of macrophages, which subsequently contributes to the inhibition of CRC.

Graphical abstract: Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo

Supplementary files

Article information

Article type
Paper
Submitted
21 Mar 2019
Accepted
10 Jun 2019
First published
14 Jun 2019

Food Funct., 2019,10, 4269-4279

Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo

M. Guo, Z. Li, Y. Huang and M. Shi, Food Funct., 2019, 10, 4269 DOI: 10.1039/C9FO00595A

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