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Issue 9, 2019
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Effect of lemon water soluble extract on hyperuricemia in a mouse model

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Abstract

Lemon is a healthy fruit with high medicinal value. This study found that lemon water soluble extract (LET) can reduce uric acid levels in mice with potassium oxonate induced hyperuricemia. Histopathological analysis suggested that LET caused little damage to the kidneys of mice. It affected mABCG2 and mGLUT9 mRNA expression only in hyperuricemic mice, but not in healthy mice. Our further results show that potassium citrate, rather than citric acid, is the main ingredient in LET with a hypouricemic effect. This study also indicates that lemon does have unique medicinal value for the treatment of hyperuricemia, and that potassium citrate has the potential to be developed as a drug for hyperuricemia. Lowering uric acid through LET and potassium citrate may directly promote the degradation of excessive uric acid in patients with hyperuricemia.

Graphical abstract: Effect of lemon water soluble extract on hyperuricemia in a mouse model

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Article information


Submitted
13 Mar 2019
Accepted
08 Aug 2019
First published
04 Sep 2019

Food Funct., 2019,10, 6000-6008
Article type
Paper

Effect of lemon water soluble extract on hyperuricemia in a mouse model

L. Chen, M. Li, J. Wu, J. Li and Z. Ma, Food Funct., 2019, 10, 6000
DOI: 10.1039/C9FO00509A

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