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Issue 5, 2019
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trans-Cinnamaldehyde mitigated intestinal inflammation induced by Cronobacter sakazakii in newborn mice

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Abstract

Necrotizing enterocolitis (NEC) is a serious intestinal disease associated with a high mortality (40–60%) in newborn infants. Cronobacter sakazakii is an important factor for NEC. However, studies regarding NEC pathogenesis and therapeutic treatments are still limited. Here, a C. sakazakii-induced mouse neonatal intestinal inflammation model was employed to determine the effects of trans-cinnamaldehyde (TC) on infections. TC treatment reduced the number of C. sakazakii colony-forming units in the ileal tissues and mitigated the morphological damage in intestinal tissues. Additionally, it reduced the mRNA transcription of inflammatory genes and production of interleukin 6 and tumor necrosis factor-α in mice infected with C. sakazakii. Moreover, TC treatment suppressed caspase-3 activity, modulated enterocyte apoptosis, and inhibited the nuclear factor-kappa B signaling pathway activation induced by C. sakazakii. These findings suggest that TC has protective effects on C. sakazakii-induced murine intestinal inflammation and that it may be a potential agent for preventing NEC.

Graphical abstract: trans-Cinnamaldehyde mitigated intestinal inflammation induced by Cronobacter sakazakii in newborn mice

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Article information


Submitted
26 Feb 2019
Accepted
02 May 2019
First published
10 May 2019

Food Funct., 2019,10, 2986-2996
Article type
Paper

trans-Cinnamaldehyde mitigated intestinal inflammation induced by Cronobacter sakazakii in newborn mice

G. Yang, T. Jin, S. Yin, D. Guo, C. Zhang, X. Xia and C. Shi, Food Funct., 2019, 10, 2986
DOI: 10.1039/C9FO00410F

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