Jump to main content
Jump to site search


Modulation of gut microbiota by chlorogenic acid pretreatment on adrenocorticotropic hormone induced depression-like behavior rats.

Abstract

Gut microbiota dysbiosis has been implicated as a vital element in the development or exacerbation of mental disorders, such as major depression disorder (MDD). Based on the current interest in the gut-brain axis, we investigate the effects of chlorogenic acid (CGA) on gut microbiota in a rat model of MDD. Depression was induced by adrenocorticotropic hormone (ACTH, 100 μg/rat) in male Wistar rats, which were intervened by saline or CGA (500 mg/kg). Behavioral changes and serum parameters were assessed and fecal samples were analyzed by 16S rRNA gene sequencing. Our studies demonstrated that CGA pretreatment ameliorated depressive-like behavior (SPT, FST, TST, OFT) and serum biochemical levels (5-HT, DA, IL-6, TNF-α) in ACTH-induced depression rats. In addition, CGA ameliorated the decrease in fecal microbiota diversity in ACTH-treated rats. Especially at the genus level, the changes in the relative abundance of some key bacteria like Desulfovibrionales, Desulfovibrio, Klebsiella, Burkholderiales, and Bifidobacterium was modulated by CGA pretreatment. These results indicated that CGA could modify gut microbial community structure, which may contribute to its antidepressant effects.

Back to tab navigation

Publication details

The article was received on 29 Dec 2018, accepted on 13 Apr 2019 and first published on 15 Apr 2019


Article type: Paper
DOI: 10.1039/C8FO02599A
Citation: Food Funct., 2019, Accepted Manuscript

  •   Request permissions

    Modulation of gut microbiota by chlorogenic acid pretreatment on adrenocorticotropic hormone induced depression-like behavior rats.

    J. Song, N. Zhou, W. Ma, X. Gu, B. Chen, Y. Zeng, L. Yang and M. Zhou, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02599A

Search articles by author

Spotlight

Advertisements