Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in liver-brain axis

Abstract

Systemic inflammation is an important determinant of synaptic dysfunction, but the underlying molecular mechanisms remain elusive. Lycopene (LYC), a major carotenoid present in tomato, has been regarded as a nutraceutical that has powerful antioxidant and antiobesity bioactivities. In the current study, we randomly assigned 3-month-old C57BL/6J mice to 3 groups: the control, LPS and LPS+LYC group ( LYC, 0.03%, w/w, mixed into normal chow) for 5 weeks, and then the mice were treated by intraperitoneal injection of LPS (0.25mg/kg) for 9 days. We showed that LYC supplementation effectively attenuated LPS-elicited neuronal damage and synaptic dysfunction through increasing the expressions of neurotrophic factors, SNAP-25 and PSD-95. LYC ameliorated LPS-induced insulin resistance and mitochondrial dysfunction in mice brains and livers. LYC alleviated neuroinflammation and hepatic inflammation. Furthermore, LYC decreased circulating insulin level and proinflammatory mediators LPS, TNF-α, IL-1β and IL-6 levels. All these results indicated that the supplementation of LYC might be a nutritional preventive strategy in systemic inflammation-induced synaptic dysfunction.

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Dec 2018, accepted on 09 Mar 2019 and first published on 14 Mar 2019


Article type: Paper
DOI: 10.1039/C8FO02460J
Citation: Food Funct., 2019, Accepted Manuscript

  •   Request permissions

    Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in liver-brain axis

    J. Wang, Q. Zou, Y. Suo, X. Tan, T. Yuan, Z. Liu and X. Liu, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02460J

Search articles by author

Spotlight

Advertisements