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Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers

Abstract

Phycocyanin (PC), a water-soluble biliprotein, exhibits potent anti-colon cancer properties. However, its application in functional foods is limited by the poor stability and low bioavailability of PC. In this study, we successfully encapsulated PC by coaxial electrospinning. The colon targeted release of PC was achieved with retention of the antioxidant activity of PC. The PC-loaded electrospun fiber mat (EFM) obtained inhibited HCT116 cell growth in a dose-dependent and time-dependent manner. In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking cell cell cycle at G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailibility, thus, it representes a promising approach for encapsulating functional ingredients for colon cancer prevention.

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Publication details

The article was received on 11 Dec 2018, accepted on 10 Feb 2019 and first published on 12 Feb 2019


Article type: Paper
DOI: 10.1039/C8FO02447B
Citation: Food Funct., 2019, Accepted Manuscript

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    Targeted delivery of phycocyanin for prevention of colon cancer using electrospun fibers

    P. Wen, T. Hu, Y. Wen, R. J. Linhardt, M. Zong, Y. Zou and H. Wu, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02447B

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