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Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets

Abstract

Antibiotics are commonly provided to weaned piglets, however, this practice has become controversial due to increased occurrences of microbial resistance, and alternatives are needed. This study aimed to investigate the effects of dietary supplementation with yeast glycoprotein (YG) or antibiotics on growth performance, intestinal mucosal morphology, immune response and colonic microbiome in weaned piglets. A total of 240 weaned piglets (d 23 ± 2) from 16 pens (15 piglets/pen) were randomly assigned into an antibiotics group (25% Quinocetone 200 mg/kg and 4% Enduracidin 800 mg/kg of the basal diet), or a YG group (800 mg/kg YG of the diet), respectively. One piglet per pen was chosen to collect plasma, intestinal tissue and colonic digesta samples after 14 days feedings. The results indicate that piglets fed diets containing YG tended to increase final body weight (0.05<P<0.1), increased average daily gain (P<0.05) and decreased F/G (P<0.05) when compared with antibiotics group. Moreover, intestinal permeability showed that YG led to lower serum content of DAO (P<0.01). Histological evaluations showed that YG contributed to improving the intestinal development via increasing villous height (P<0.05) and the villous height to crypt depth ratio (P<0.01), decreasing crypt depth (P<0.01) and villous width (P<0.05) in the ileum. Intestinal integrity also showed that YG conduced to improving the intestinal development via upregulating the m-RNA expression of occludin (P<0.05) in the duodenal and jejunal mucosa. Interestingly, YG supplement downregulated the m-RNA expression of IL-12 (P<0.05), upregulated the m-RNA expression of Hsp-70 (P<0.05) in the duodenal mucosa, downregulated the m-RNA expression of Hsp-70 (P<0.05), IFN-γ (P<0.05), upregulated the m-RNA expression of Hsp-90 (P<0.05) in the jejunal mucosa, and upregulated the m-RNA expression of Hsp-70 (P<0.05) in the ileal mucosa. On the other hand, colonic microbiome results showed that YG supplement increased the relative abundance of Lactobacillus (P<0.05). Colonic metabolites results showed that YG supplement decreased the content of acetate (P<0.05). Taken together, it is speculated that YG would be a potent alternative to prophylactic antibiotics in improving the gut health in weaned piglets.

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Publication details

The article was received on 26 Nov 2018, accepted on 12 Mar 2019 and first published on 14 Mar 2019


Article type: Paper
DOI: 10.1039/C8FO02327A
Citation: Food Funct., 2019, Accepted Manuscript

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    Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets

    L. Qin, W. Ji, B. Li, J. Wang, J. Hu and X. WU, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO02327A

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