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Impacts of natural polysaccharides on the intestinal microbiota and immune responses–A review


In recent years, natural polysaccharides have received increasing attention and become one kind of popular dietary nutrients owing to their various biological functions. Similarly, intestinal microbiota is a hot topic because it is closely associated with human health. Firstly, the summary of microbiota includes methods to study intestinal microorganisms, the changes in microbial composition and main factors to affect gut microbiota composition. Besides, the summary of the immune system contains information on T cells, macrophages, innate lymphoid cells and pattern recognition receptors. Meanwhile, the summary of polysaccharides mainly introduces source, extraction and purification methods, and structural determination of polysaccharides. Gut microbiota can affect the immune system through its composition, structural components and metabolites, while immune deficiency gives rise to dysbiosis of intestinal microbes. Natural polysaccharides not only enhance immunity, but also suppress excessive immune responses caused by various stimuli through directly regulating immune cells or/and improving microbial composition. Notably, natural polysaccharides exhibit potential applications in functional foods due to their abilities to suppress inflammation and cancer. Therefore, we present a comprehensive overview on the gut microbiota, immunity and polysaccharides in many aspects.

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Publication details

The article was received on 06 Oct 2018, accepted on 12 Apr 2019 and first published on 15 Apr 2019

Article type: Review Article
DOI: 10.1039/C8FO01946K
Citation: Food Funct., 2019, Accepted Manuscript

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    Impacts of natural polysaccharides on the intestinal microbiota and immune responses–A review

    C. Tang, R. Ding, J. Sun, J. Liu, J. Kan and C. Jin, Food Funct., 2019, Accepted Manuscript , DOI: 10.1039/C8FO01946K

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