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Issue 6, 2019
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A water-soluble BODIPY based ‘OFF/ON’ fluorescent probe for the detection of Cd2+ ions with high selectivity and sensitivity

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Abstract

A water-soluble dilithium salt BODIPY derivative (LiBDP) with appended dicarboxylate pseudo-crown ether [NO4] coordinating sites has been designed, synthesized and characterized successfully for the selective and sensitive recognition of Cd2+ in aqueous media. The chemosensor exhibits a remarkable increase in fluorescence intensity as well as a distinct color change upon the addition of Cd2+ over other environmentally and biologically relevant metal ions in H2O. The fluorometric response of LiBDP is attributed to the metal chelation-enhanced fluorescence (MCHEF) effect which has been confirmed by a strong association constant of 2.57 ± 1.06 × 105 M−1 and Job's plot, indicating 1 : 1 binding stoichiometry between LiBDP and Cd2+. Frontier molecular orbital analysis (obtained from DFT studies) also illustrates the turn-on fluorescence of the probe by blocking photoinduced electron transfer (PET) after coordination to Cd2+. The probe can detect Cd2+ in a competitive environment up to a submicromolar level in a biologically significant pH range. The sensor is proved to be reversible and reusable by the alternative addition of Cd2+ followed by S2−. The OFF/ON/OFF sensing behavior is utilized to construct an INHIBIT molecular logic gate based on the two inputs of Cd2+ and S2− and a fluorescence intensity at 512 nm as an output. The test paper experiment demonstrates the practical utility of LiBDP to monitor Cd2+ in an aqueous sample. Finally, the sensing probe was utilized to monitor Cd2+ in living cells.

Graphical abstract: A water-soluble BODIPY based ‘OFF/ON’ fluorescent probe for the detection of Cd2+ ions with high selectivity and sensitivity

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Publication details

The article was received on 06 Oct 2018, accepted on 09 Jan 2019 and first published on 10 Jan 2019


Article type: Paper
DOI: 10.1039/C8DT04016H
Dalton Trans., 2019,48, 2108-2117

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    A water-soluble BODIPY based ‘OFF/ON’ fluorescent probe for the detection of Cd2+ ions with high selectivity and sensitivity

    A. Maity, U. Ghosh, D. Giri, D. Mukherjee, T. K. Maiti and S. K. Patra, Dalton Trans., 2019, 48, 2108
    DOI: 10.1039/C8DT04016H

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