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Issue 10, 2019
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C–H functionalization reactions under flow conditions

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C–H functionalization technologies have progressed enormously in the last decade as testified by the great number of publications that have appeared in the literature, which are receiving great attention from researchers from different areas of expertise. While most of the protocols reported realize the C–H functionalization processes under batch conditions, there is a growing interest in the development of continuous-flow procedures aiming at increasing the performances of established methodologies or the definition of otherwise unfeasible transformations. This review summarizes the application of flow technologies for the realization of C–H functionalization reactions. According to the type of flow reactors necessary, two main general approaches are possible for the application of flow techniques, namely the use of homogeneous or heterogeneous conditions. Each example is discussed and accompanied by the description of the main features and benefits of the use of flow compared to batch conditions.

Graphical abstract: C–H functionalization reactions under flow conditions

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Article information

24 Nov 2018
First published
03 Apr 2019

Chem. Soc. Rev., 2019,48, 2767-2782
Article type
Review Article

C–H functionalization reactions under flow conditions

S. Santoro, F. Ferlin, L. Ackermann and L. Vaccaro, Chem. Soc. Rev., 2019, 48, 2767
DOI: 10.1039/C8CS00211H

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