Quick temperature-swept pure-shift NMR: case of solvent effects in atorvastatin
Pure-shift NMR experiments provide highly resolved spectra, that could be perfect for precise monitoring of chemical shift variations under different conditions, such as temperature or concentration. However, their sensitivity is quite low and signal sampling is time-consuming, leading to long experimental times and making such serial acquisition problematic. In this paper we present a new method of NMR spectroscopy improving the speed and sensitivity of serial pseudo-two-dimensional pure-shift experiments. The example of variable-temperature study of atorvastatin reveals the potential of the method in verifying the theoretical predictions of solvent-dependent spectral effects.