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Co-crystallization and polymorphic behaviour of 5-fluorouracil

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Abstract

Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.

Graphical abstract: Co-crystallization and polymorphic behaviour of 5-fluorouracil

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Publication details

The article was received on 05 Oct 2018, accepted on 12 Nov 2018 and first published on 13 Nov 2018


Article type: Paper
DOI: 10.1039/C8CE01692E
Citation: CrystEngComm, 2019, Advance Article
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    Co-crystallization and polymorphic behaviour of 5-fluorouracil

    D. D. Enkelmann, J. Handelmann, C. Schauerte and K. Merz, CrystEngComm, 2019, Advance Article , DOI: 10.1039/C8CE01692E

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