Issue 100, 2019
From the journal:

Chemical Communications

A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections†

Dongliang Yang, ORCID logo a   Xinyi Lv,a   Lei Xue,a   Nan Yang,a   Yanling Hu,*b   Lixing Weng,c   Nina Fu,*c   Lianhui Wang ORCID logo c  and  Xiaochen Dong ORCID logo *ad  

* Corresponding authors

a School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China
E-mail: iamxcdong@njtech.edu.cn

b School of Electrical and Control Engineering, Nanjing Polytechnic Institute, No. 625, Geguan Road, Nanjing City, Jiangsu, China
E-mail: huyanling@njpi.edu.cn

c Institute of Advanced Materials (IAM) and Jiangsu Key Laboratory for Biosensors, Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
E-mail: iamnnfu@njupt.edu.cn

d School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing, China

Abstract

A lipase-triggered drug release nanoplatform (PGL-DPP–FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP–FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP–FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

Graphical abstract: A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

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Article information

DOI
https://doi.org/10.1039/C9CC08463K
Article type
Communication
Submitted
30 Oct 2019
Accepted
25 Nov 2019
First published
25 Nov 2019

Chem. Commun., 2019,55, 15145-15148

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A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

D. Yang, X. Lv, L. Xue, N. Yang, Y. Hu, L. Weng, N. Fu, L. Wang and X. Dong, Chem. Commun., 2019, 55, 15145 DOI: 10.1039/C9CC08463K

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