Jump to main content
Jump to site search

Issue 97, 2019
Previous Article Next Article

Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor

Author affiliations

Abstract

On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time. Incorporation of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer permitted real-time monitoring of resin swelling to determine amino acid coupling efficiency and on-resin aggregation.

Graphical abstract: Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Oct 2019, accepted on 11 Nov 2019 and first published on 11 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08421E
Chem. Commun., 2019,55, 14598-14601
  • Open access: Creative Commons BY license
  •   Request permissions

    Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor

    E. T. Sletten, M. Nuño, D. Guthrie and P. H. Seeberger, Chem. Commun., 2019, 55, 14598
    DOI: 10.1039/C9CC08421E

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements