Issue 100, 2019

Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

Abstract

We report a novel nanophotosensitizer via one-step covalent assembly of dopamine and genipin. This is the first report unveiling the photodynamic effect of dopamine-based materials. These nanophotosensitizers can also act as pH-responsive drug nanocarriers via a catechol–boronate linkage, thus achieving combined PDT and chemotherapy for highly efficient cancer treatment.

Graphical abstract: Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
23 Oct 2019
Accepted
20 Nov 2019
First published
21 Nov 2019

Chem. Commun., 2019,55, 15057-15060

Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

H. Li, Y. Zhao, Y. Jia, C. Qu and J. Li, Chem. Commun., 2019, 55, 15057 DOI: 10.1039/C9CC08294H

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