Issue 95, 2019
From the journal:

Chemical Communications

A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly†

Jie Gao,‡a   Huijuan Yu,‡b   Fang-Yuan Chen,a   Xin-Yue Hu,a   Yuefei Wang*b  and  Dong-Sheng Guo ORCID logo *a  

* Corresponding authors

a College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, P. R. China
E-mail: dshguo@nankai.edu.cn

b Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
E-mail: wangyf0622@tjutcm.edu.cn

Abstract

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.

Graphical abstract: A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

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Article information

DOI
https://doi.org/10.1039/C9CC08199B
Article type
Communication
Submitted
19 Oct 2019
Accepted
04 Nov 2019
First published
05 Nov 2019

Chem. Commun., 2019,55, 14387-14390

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A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

J. Gao, H. Yu, F. Chen, X. Hu, Y. Wang and D. Guo, Chem. Commun., 2019, 55, 14387 DOI: 10.1039/C9CC08199B

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