Issue 93, 2019

A novel method to engineer proteases for selective enzyme inhibition

Abstract

In this work, we have proposed a new strategy to expand the function of a protein. By taking a protease as an example, it can be engineered to make up the shortcoming of natural proteases, and thus it can efficiently and selectively hydrolyze a desired protein even in a complex biological fluid.

Graphical abstract: A novel method to engineer proteases for selective enzyme inhibition

Supplementary files

Article information

Article type
Communication
Submitted
15 Oct 2019
Accepted
29 Oct 2019
First published
30 Oct 2019

Chem. Commun., 2019,55, 14039-14042

A novel method to engineer proteases for selective enzyme inhibition

L. Li, H. Shi, A. Sheng, Y. Yang, L. Shi, C. Li and G. Li, Chem. Commun., 2019, 55, 14039 DOI: 10.1039/C9CC08085F

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