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Issue 97, 2019
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Nickel-catalyzed electrochemical reductive decarboxylative coupling of N-hydroxyphthalimide esters with quinoxalinones

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Abstract

Herein the first example of electrochemically enabled, NiCl2-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxylative coupling allows access to structurally diverse 3-alkylated quinoxalinones in up to 91% yields.

Graphical abstract: Nickel-catalyzed electrochemical reductive decarboxylative coupling of N-hydroxyphthalimide esters with quinoxalinones

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Publication details

The article was received on 06 Oct 2019, accepted on 11 Nov 2019 and first published on 12 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07840A
Chem. Commun., 2019,55, 14685-14688

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    Nickel-catalyzed electrochemical reductive decarboxylative coupling of N-hydroxyphthalimide esters with quinoxalinones

    F. Lian, K. Xu, W. Meng, H. Zhang, Z. Tan and C. Zeng, Chem. Commun., 2019, 55, 14685
    DOI: 10.1039/C9CC07840A

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