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Issue 95, 2019
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The hydrophobically-tagged MDM2–p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

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Abstract

We present the first application of hydrophobic tagging to a non-covalent inhibitor of protein–protein interactions. Nutlin-3a-HT, created by fusing the hydrophobic tag HyT13 to the MDM2–p53 interaction inhibitor Nutlin-3a, prevented cellular accumulation of MDM2 upon p53 reactivation, and had a stronger effect on cell viability and the induction of apoptosis than Nutlin-3a.

Graphical abstract: The hydrophobically-tagged MDM2–p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

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Publication details

The article was received on 04 Oct 2019, accepted on 04 Nov 2019 and first published on 05 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07795B
Chem. Commun., 2019,55, 14351-14354
  • Open access: Creative Commons BY license
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    The hydrophobically-tagged MDM2–p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

    F. Nietzold, S. Rubner and T. Berg, Chem. Commun., 2019, 55, 14351
    DOI: 10.1039/C9CC07795B

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