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Issue 97, 2019
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Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration

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Abstract

The association of hydrophobic cavities with porphyrin derivatives has been used to mimic haemoprotein structures. The most employed cavity in this field is β-cyclodextrin (β-CD), and scaffolds combining β-CDs and porphyrins are expected to inspire the combination of porphyrins and cucurbiturils in the near future. Aside from providing water solubility to various porphyrinic structures, the β-CD framework can also modulate and control the reactivity of the metal core of the porphyrin. After a general introduction of the challenges faced in the field of haemoprotein models and the binding behavior of β-CDs, this article will discuss covalent and non-covalent association of porphyrins with β-CDs. In each approach, the role of the CD differs according to the relative position of the concave CD host, either directly controlling the binding and transformation of a substrate on the metalloporphyrin or playing a dual role of controlling the water solubility and selecting the axial ligand of the metal core. The discussion will be of interest to the cucurbituril community as well as to the cavitand community, as the information provided should be useful for the design of haemoprotein mimics using cucurbiturils.

Graphical abstract: Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration

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Publication details

The article was received on 25 Sep 2019, accepted on 09 Nov 2019 and first published on 11 Nov 2019


Article type: Feature Article
DOI: 10.1039/C9CC07545C
Chem. Commun., 2019,55, 14558-14565

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    Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration

    M. Vonesch, J. A. Wytko, H. Kitagishi, K. Kano and J. Weiss, Chem. Commun., 2019, 55, 14558
    DOI: 10.1039/C9CC07545C

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