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Issue 97, 2019
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Thermoresponsive drug delivery to mitochondria in vivo

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Abstract

Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.

Graphical abstract: Thermoresponsive drug delivery to mitochondria in vivo

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Publication details

The article was received on 25 Sep 2019, accepted on 11 Nov 2019 and first published on 11 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07538K
Chem. Commun., 2019,55, 14645-14648

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    Thermoresponsive drug delivery to mitochondria in vivo

    L. Ruan, M. Zhou, J. Chen, H. Huang, J. Zhang, H. Sun, Z. Chai and Y. Hu, Chem. Commun., 2019, 55, 14645
    DOI: 10.1039/C9CC07538K

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