Issue 98, 2019
From the journal:

Chemical Communications

Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis†

Haiyan Dong,*a   Bo Lu,a   Jie Wang,c   Jingjing Xie,d   Kuancan Liu,e   Lee Jia ORCID logo c  and  Junyang Zhuang ORCID logo *b  

* Corresponding authors

a Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University, Fuzhou, Fujian 350108, China
E-mail: cmopdhy@163.com

b The Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China
E-mail: Junyang.Zhuang@hotmail.com

c Institute of Oceanography, Minjiang College, Fuzhou, Fujian 350116, China

d School of Pharmaceutical Sciences, and Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China

e Institute for Laboratory Medicine, 900 Hospital of the Joint Logistics Team or Dongfang Hospital, Fuzhou, Fujian, China

Abstract

We propose a novel fluorescence assay method by designing a polymerization-driven DNA dominoes collapse (PDDC) strategy, enabling highly sensitive detection of p53 gene (as a model analyte) and single nucleotide polymorphism analysis.

Graphical abstract: Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

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Article information

DOI
https://doi.org/10.1039/C9CC07508A
Article type
Communication
Submitted
24 Sep 2019
Accepted
17 Nov 2019
First published
18 Nov 2019

Chem. Commun., 2019,55, 14797-14800

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Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

H. Dong, B. Lu, J. Wang, J. Xie, K. Liu, L. Jia and J. Zhuang, Chem. Commun., 2019, 55, 14797 DOI: 10.1039/C9CC07508A

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