Issue 94, 2019

Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

Abstract

A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.

Graphical abstract: Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

Supplementary files

Article information

Article type
Communication
Submitted
13 Sep 2019
Accepted
04 Nov 2019
First published
04 Nov 2019

Chem. Commun., 2019,55, 14162-14165

Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

K. Sambath, T. Zhao, Z. Wan and Y. Zhang, Chem. Commun., 2019, 55, 14162 DOI: 10.1039/C9CC07199G

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