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Issue 95, 2019
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A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

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Abstract

A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing drug-induced hepatotoxicity and its remediation by using hepatoprotective medicines in living cells and mice.

Graphical abstract: A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

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Publication details

The article was received on 09 Sep 2019, accepted on 04 Nov 2019 and first published on 12 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07017F
Chem. Commun., 2019,55, 14307-14310

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    A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

    W. Jiang, Y. Li, W. Wang, Y. Zhao, J. Fei and C. Li, Chem. Commun., 2019, 55, 14307
    DOI: 10.1039/C9CC07017F

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