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Issue 95, 2019
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Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

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Abstract

In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.

Graphical abstract: Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

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Publication details

The article was received on 02 Sep 2019, accepted on 01 Nov 2019 and first published on 01 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC06828G
Chem. Commun., 2019,55, 14283-14286
  • Open access: Creative Commons BY-NC license
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    Iridium(III) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

    V. N. Kozhevnikov, M. E. Deary, T. Mantso, M. I. Panayiotidis and M. T. Sims, Chem. Commun., 2019, 55, 14283
    DOI: 10.1039/C9CC06828G

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