A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells

Heng Xiao; Huiling Fan; Luming Xu; Zhiyin Pei; Shijun Lei; Jinglei Xu; Jiangbo Xi; Guobin Wang; Lin Wang; Zheng Wang

doi:10.1039/C9CC06674H

A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells†

Heng Xiao,‡^ab Huiling Fan,‡^b Luming Xu,‡^b Zhiyin Pei,^b Shijun Lei,^b Jinglei Xu,^c Jiangbo Xi,

^d Guobin Wang,*^e Lin Wang*^ab and Zheng Wang

*^be

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* Corresponding authors

^a Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

^b Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
E-mail: lin_wang@hust.edu.cn, zhengwang@hust.edu.cn

^c College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, Hubei, China

^d School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China

^e Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
E-mail: zhengwang@hust.edu.cn, wgb@hust.edu.cn

Abstract

We report a new biofunctionalized nanoplatform based on hyaluronic acid-coated gold-nano-dot-decorated hollow carbon nanospheres (AuHCNs-HA) for microRNA imaging in living cells. Importantly, the HA-coated nanoplatform could be internalized into target cells via CD44 receptor-mediated endocytosis. It can be further applied for intracellular miR-21 imaging in CD44-positive colorectal cancer cells.

Chemical Communications

A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells†

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A gold-nanodot-decorated hollow carbon nanosphere based nanoplatform for intracellular miRNA imaging in colorectal cancer cells

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